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Related Experiment Videos

Variability of routine pulmonary function tests.

J Hruby, J Butler

    Thorax
    |October 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Pulmonary function tests show significant daily variations, especially in airway resistance. These natural fluctuations can mimic disease progression, highlighting the need for standardized testing times.

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    Area of Science:

    • Pulmonary Medicine
    • Respiratory Physiology

    Background:

    • Pulmonary function tests (PFTs) can show apparent "stepwise" changes in lung function.
    • Interpreting these changes requires understanding natural variations in PFTs.

    Purpose of the Study:

    • To quantify diurnal and random variability in key pulmonary function tests.
    • To assess the impact of variability on interpreting lung function changes over time.

    Main Methods:

    • Repeatedly measured vital capacity (VC), forced expiratory volume in 1 second (FEV1), forced residual capacity (FRC), and airway resistance (Raw).
    • Included normal subjects, patients with obstructive airways disease, and patients with restrictive lung disease.

    Main Results:

    • Significant diurnal variation (P < 0.001) observed in Raw, with highest values in the morning and lowest at midday.

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  • Midday Raw values were approximately 80% of the highest daily values.
  • Individual variability ranged up to 81% for Raw, 62% for FRC, 30% for VC, and 29% for FEV1.

    • Conclusions:

    • The natural variability in PFTs, particularly Raw, can be misinterpreted as disease progression or therapeutic response.
    • Standardizing the time of day for PFTs is crucial for accurate assessment of disease progress and treatment efficacy.