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Related Experiment Videos

Primary pancreatic lymphoma.

L Boni1, A Benevento, G Dionigi

  • 1Department of Surgery, University of Insubria, Ospedale di Circolo di Varese, Viale Borri n. 57, 21100 Varese, Italy. bonil@tin.it

Surgical Endoscopy
|May 2, 2002
PubMed
Summary
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Primary pancreatic lymphoma (PPL) is a rare pancreatic tumor. This case highlights the diagnostic challenges and successful treatment of a patient with PPL presenting with severe weight loss and diabetic crisis.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Primary pancreatic lymphoma (PPL) is an extremely rare extranodal lymphoma, accounting for less than 0.5% of pancreatic tumors.
  • PPL often presents with symptoms and imaging findings similar to other pancreatic masses, necessitating thorough histopathological examination for diagnosis.

Observation:

  • A 46-year-old male presented with severe weight loss, watery diarrhea, and diabetic crisis.
  • Imaging revealed a pancreatic head mass and lymphadenopathy; however, initial fine-needle aspiration (FNA) and lymph node biopsy were inconclusive.
  • Diagnostic laparoscopy with biopsies confirmed primary low-grade non-Hodgkin B cell pancreatic lymphoma.

Findings:

  • Histopathological examination of pancreatic and lymph node biopsies was crucial for definitive diagnosis.

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  • The patient successfully underwent chemotherapy for low-grade B cell lymphoma and remained symptom-free at 9-month follow-up.

    • Implications:

    • This case underscores the importance of considering PPL in the differential diagnosis of pancreatic masses, especially in patients with atypical presentations.
    • Advanced diagnostic techniques, including laparoscopy and detailed histopathology, are vital for diagnosing rare pancreatic malignancies.
    • Timely diagnosis and appropriate chemotherapy can lead to favorable outcomes in patients with primary pancreatic lymphoma.