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[Hepatocytes growth factor (HGF), leptin, neopterin serum concentrations in patients with chronic hepatitis C]
K Zwirska-Korczala1, A P Dziambor, A Wiczkowski
1Katedra i Zakład Fizjologii w Zabrzu Slaskiej Akademii Medycznej w Katowicach.
Insights
In patients with chronic hepatitis C, elevated serum leptin, HGF, and neopterin levels were observed. These biomarkers may indicate liver inflammation and damage severity in hepatitis C patients.
Area of Science:
- Biochemistry
- Immunology
- Hepatology
Context:
- Chronic hepatitis C is a significant global health concern.
- Assessing liver inflammation and damage is crucial for patient management.
- Biomarkers can offer insights into disease activity and progression.
Purpose:
- To evaluate serum concentrations of leptin, hepatocyte growth factor (HGF), and neopterin in patients with chronic hepatitis C.
- To determine the correlation between these biomarkers and indicators of liver disease severity, including inflammatory grading, fibrosis staging, and GGTP activity.
Summary:
- Serum concentrations of leptin, HGF, and neopterin were significantly higher in 18 chronic hepatitis C patients compared to controls.
- Leptin levels correlated with liver biopsy inflammatory grading.
- HGF concentrations were associated with fibrosis staging, while neopterin correlated with both inflammatory and fibrosis parameters, as well as GGTP activity.
Impact:
- Increased neopterin may indicate active liver inflammation.
- Leptin and HGF serum levels could serve as indicators of liver damage intensity in chronic hepatitis C.
- These findings suggest potential utility of these biomarkers in monitoring hepatitis C progression and treatment response.
Unlabelled:
In 18 patients with chronic hepatitis C we evaluated leptin (with IRMA method) and HGF and neopterin (with ELISA method) serum concentrations. Concentrations of leptin, HGF and neopterin were higher than in the control group. Leptin serum concentrations correlated with liver biopsy inflammatory grading, but higher HGF concentrations were connected with fibrosis staging. Neopterin correlated with both parameters and GGTP activity.
In Conclusion:
increased neopterin concentrations could inform about liver inflammation activity; leptin and HGF serum concentrations could reflect the liver damage intensity.