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[Vegetations associated with infective endocarditis in children]
1Klinika Kardiologii Instytutu, Pomnik-Centrum Zdrowia Dziecka w Warszawie.
Insights
Infective endocarditis vegetations in children most often affect the mitral valve, particularly in those without congenital heart disease. Medical treatment yielded good results in over half of the pediatric patients studied.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
- Echocardiography
Context:
- Infective endocarditis (IE) is a serious infection affecting heart valves.
- Vegetations are a key echocardiographic finding in IE.
- Understanding vegetation characteristics in children is crucial for diagnosis and management.
Purpose:
- To perform a clinical analysis of vegetations associated with infective endocarditis in pediatric patients.
- To identify the common locations and associated factors of vegetations in children with IE.
Summary:
- A study of 7 children (aged 2-17) with IE revealed vegetations predominantly on the mitral valve, especially in those without congenital heart disease (CHD).
- Clinical signs included fever (71%), new murmurs (57%), and hepatosplenomegaly (43%). Blood cultures were positive in 72% of cases.
- Medical treatment resulted in good outcomes for 57% of patients, while 3 underwent surgical intervention.
Impact:
- This study highlights the prevalence and common sites of vegetations in pediatric infective endocarditis.
- Findings emphasize the importance of echocardiography in diagnosing IE-related vegetations in children.
- Results contribute to understanding treatment outcomes for pediatric IE vegetations.
Objective:
The purpose of this study were clinical analysis of vegetations associated with infective endocarditis.
Material And Methods:
Between 1990-1999 years 7 children (aged 2-17 years) with infective endocarditis were study in the Cardiology Department Children's Memorial Health Institute. Analysed clinical features of vegetations associated with endocarditis.
Main Observations And Results:
The most of them vegetations were localized on the mitral valve and in children without congenital heart disease (CHD). Remaining patients were: girl with bicuspidal aortic valve-vegetation on the aortic valve, boy with simple ventricle, pulmonary stenosis and atrial septal defect-vegetation on the pulmonary valve, boy with double outlet right ventricle, pulmonary stenosis and atrial septal defect-vegetation on the tricuspid valve, boy with patent ductus arteriosus-vegetation on the pulmonary valve. In all patients were regurgitations of this valves (> II degree). 71% patients had fever, 57% another murmur in the heart, 43% hepatosplenomegalia. Positive result of the blood sowing was in 72% patients. After medical treatment of vegetations good result was in 4 children. Chirurgical treatment were performance in 3 children.
Conclusions:
1. Vegetations in the echocardiographic examination were in 21.8% children associated with infective endocarditis. 2. The most of them vegetations were localized on the mitral valve and in children without CHD. 3. Good result after medical treatment of vegetations was in 57% patients.