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Updated: Oct 1, 2026

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
Published on: December 28, 2013
[Effect of almitrine/raubasine on cerebral metabolism in the elderly]
1Laboratoire de Pharmacologie Expérimentale et Clinique Faculté de Médecine, Université de Rennes 1 2, avenue du Professeur Léon Bernard CS34317 35043 Rennes. Herve.Allain@univ-rennes1.fr
Abstract:
Recent neurobiological data has led to renewed interest in oxygen (O2). The discovery of neuroglobin, protein varyingly present in the brain, has been enhanced by the elucidation of the mechanisms through which oxygen intervenes in neuronal metabolism. Almitrine/raubasine activates the metabolism of hypoxic/ischemic neurones by increasing O2 bioavailability. This mechanism supports the effects on behaviour obtained in various animal models and the benefits observed during clinical trials in elderly patients presenting with cognitive defects.
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