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Published on: November 29, 2013
Repeated imipramine administration enhances the effects of NMDA receptor ligands on synchronous activity in rat
1Department of Physiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków. bobula@if-pan.krakow.pl
Abstract:
This study assessed the effects of repeated administration (14 days) of imipramine on the function of NMDA receptors by measuring the frequency of spontaneous epileptiform discharges which develop in rat frontal cortical slices incubated in Mg2+-free conditions. Imipramine significantly enhanced both the excitatory effect of NMDA and the inhibitory effect of the competitive NMDA receptor antagonist CGP 37849 on the frequency of discharges. These results are consistent with studies indicating that chronic administration of antidepressant drugs induces adaptive changes in NMDA receptor/ channel complex in the cerebral cortex.
