Effect of repeated treatment with reboxetine on the central alpha1-adrenergic system

The obtained results indicate that repeated administration of reboxetine (selective noradrenaline reuptake inhibitor, without any affinity for neurotransmitter receptors) increased the responsiveness of alpha1-adrenergic system (potentiating the methoxamine-induced exploratory hyperactivity in rats and clonidine-induced aggressiveness in mice), as tricyclic antidepressants did. However, the question whether the increased functional responsiveness found in the present study is important for the clinical antidepressant efficacy, remains open.