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Decrease in heart ventricular ejection fraction during multiple sclerosis.

S Olindo1, B Guillon, J Helias

  • 1Department of Neurology, CHU G et R Laennec, Nantes, France. olindo.stephane@wanadoo.fr

European Journal of Neurology
|May 3, 2002
PubMed
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Multiple sclerosis (MS) patients show decreased right and left ventricular ejection fractions (VEFs) compared to healthy individuals. This cardiac function decline in MS may be linked to autonomic impairment, warranting further investigation.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Imaging

Background:

  • Mitoxantrone is an effective treatment for active multiple sclerosis (MS), often requiring cardiac monitoring.
  • Ventricular ejection fractions (VEFs) in MS patients have not been previously compared to control groups.

Purpose of the Study:

  • To assess and compare right and left ventricular ejection fractions (VEFs) in multiple sclerosis (MS) patients versus a control group.
  • To identify potential cardiac function changes in MS patients.

Main Methods:

  • Radionuclide angiocardiography (RA) was used to measure resting right and left VEFs in 40 MS patients and 40 healthy controls.
  • Normal VEF ranges were established from the control group.

Main Results:

Related Experiment Videos

  • MS patients exhibited statistically significant decreases in both right (P=0.02) and left (P < 0.0001) VEFs compared to controls.
  • 25% of MS patients showed abnormal VEF results (right, left, or both).
  • No correlation was found between VEF and MS disease characteristics (duration, severity, course) or patient demographics.

Conclusions:

  • Multiple sclerosis patients demonstrate reduced right and left ventricular ejection fractions.
  • Autonomic dysfunction, common in MS, is a potential factor contributing to decreased VEFs.
  • Further research is needed to elucidate the specific physiological factors responsible for VEF reduction in MS.