Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effects of LDL cholesterol on vascular function.

C Rosendorff1

  • 1Mount Sinai School of Medicine, New York, NY, and the V.A. Medical Center, Bronx, NY 10468, USA.

Journal of Human Hypertension
|May 3, 2002
PubMed
Summary

Oxidised low-density lipoprotein (LDL) cholesterol constricts blood vessels, potentiating noradrenaline effects and impairing vasodilation. Lipid-lowering agents, L-arginine, and antioxidants can reverse these harmful vascular effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers.

Neurology·2006
Same author

Calcium antagonists and secondary prevention of myocardial infarction; [comment].

Lancet (London, England)·2000
Same author

Statins for prevention of stroke.

Lancet (London, England)·1998
Same author

The renin-angiotensin system--from Tigerstedt to Goldblatt to ACE inhibition and beyond.

The Mount Sinai journal of medicine, New York·1998
Same author

Vascular hypertrophy in hypertension: role of the renin-angiotensin system.

The Mount Sinai journal of medicine, New York·1998
Same author

Efficacy and tolerability of nisoldipine coat-core formulation in the treatment of essential hypertension: The South African Multicenter ANCHOR Study. Ambulatory Nisoldipine Coat-Core Hypertension Outpatient Response (ANCHOR) Investigators.

American journal of hypertension·1997

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Vascular Biology

Background:

  • Oxidised low-density lipoprotein (LDL) exhibits vasoconstrictor, mitogenic, pro-inflammatory, and thrombogenic properties.
  • Elevated LDL cholesterol significantly impacts vascular function, contributing to endothelial dysfunction.

Purpose of the Study:

  • To review the evidence supporting the vasoconstrictor properties of oxidised LDL cholesterol.
  • To examine the mechanisms by which LDL cholesterol affects vascular tone and endothelial function.

Main Methods:

  • Literature review of studies investigating the effects of oxidised LDL cholesterol on vascular beds.
  • Analysis of research on the impact of lipid-lowering agents, L-arginine, and antioxidants on endothelial function.

Main Results:

  • Oxidised LDL cholesterol potentiates noradrenaline-induced vasoconstriction in peripheral, coronary, cerebral, and renal vasculature.
  • Endothelium-dependent vasodilation, such as responses to acetylcholine, is blunted by oxidised LDL cholesterol.
  • Lipid-lowering therapies, L-arginine (nitric oxide precursor), and antioxidants demonstrate efficacy in reversing or mitigating these adverse vascular effects.

Conclusions:

  • Oxidised LDL cholesterol significantly impairs vascular function through vasoconstriction and blunted vasodilation.
  • Therapeutic interventions targeting lipid levels, nitric oxide pathways, and oxidative stress can improve endothelial function.
  • Further research is warranted to explore the benefits of lipid management in normocholesterolemic individuals for vascular health.

Related Experiment Videos