Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Centrosome replication, genomic instability and cancer.

A Krämer1, K Neben, A D Ho

  • 1Medizinische Klinik und Poliklinik V, Ruprecht-Karls-Universität Heidelberg, Hospitalstrasse 3, 69115 Heidelberg, Germany.

Leukemia
|May 3, 2002
PubMed
Summary

Errors in centrosome duplication lead to abnormal cell division and aneuploidy, contributing to cancer. This review explores centrosome roles in cell cycle progression and aberrant replication in human tumors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rituximab Chimeric Anti-CD20 Monoclonal Antibody Therapy for Relapsed Indolent Lymphoma: Half of Patients Respond to a Four-Dose Treatment Program.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2023
Same author

An automated approach to determine antibody endpoint titers for COVID-19 by an enzyme-linked immunosorbent assay.

Immunohematology·2021
Same author

Transplant-associated thrombotic microangiopathy is an endothelial complication associated with refractoriness of acute GvHD.

Bone marrow transplantation·2017
Same author

Addition of rituximab to CHOP-like chemotherapy in first line treatment of primary mediastinal B-cell lymphoma.

BMC cancer·2017
Same author

Molecular signaling in multiple myeloma: association of RAS/RAF mutations and MEK/ERK pathway activation.

Oncogenesis·2017
Same author

GvL effects in T-prolymphocytic leukemia: evidence from MRD kinetics and TCR repertoire analyses.

Bone marrow transplantation·2017

Area of Science:

  • Cell Biology
  • Cancer Biology
  • Genetics

Background:

  • Karyotypic alterations are common in cancer cells.
  • Errors in centrosome duplication can cause aneuploidy and contribute to cancer formation.
  • Supernumerary centrosomes are observed in most solid human tumors.

Purpose of the Study:

  • To review the role of centrosomes in cell cycle progression.
  • To discuss the causes and consequences of aberrant centrosome replication in human neoplasias.

Main Methods:

  • Literature review focusing on centrosome duplication cycle, cell cycle regulation, and cancer.
  • Analysis of recent reports linking centrosome duplication to cell division cycle regulators.
  • Examination of alterations in G(1)/S phase proteins and their impact on centrosome replication.

Related Experiment Videos

Main Results:

  • Centrosomes are crucial for accurate chromosome segregation during cell division.
  • Aberrant centrosome replication, linked to cell cycle dysregulation, can lead to karyotypic instability.
  • Alterations in cell cycle regulators (e.g., p53, cyclins, cdks) are frequent in malignancies and may drive uncontrolled centrosome replication.

Conclusions:

  • Centrosome duplication errors are a significant factor in cancer development and progression.
  • Understanding centrosome biology is vital for developing novel cancer therapies.