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Related Experiment Videos

What makes a drug a primary mood stabilizer?

P E Keck1, S L McElroy, N Richtand

  • 1Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0559, USA. keckpe@email.uc.edu

Molecular Psychiatry
|May 3, 2002
PubMed
Summary

This review examines evidence for mood stabilizers in bipolar disorder treatment. It analyzes randomized controlled trials and pharmacological mechanisms of these essential medications.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Medicine

Background:

  • The definition and application of 'mood stabilizer' for bipolar disorder treatment lack consistent criteria.
  • Clinical characteristics of bipolar disorder and properties of specific medications influence the definition of mood stabilizers.

Purpose of the Study:

  • To review evidence supporting the use of mood-stabilizing agents in bipolar disorder.
  • To explore potential pharmacological mechanisms of established mood-stabilizing compounds.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) for mood stabilizer agents.
  • Literature review of pharmacological mechanisms underlying mood stabilization.

Main Results:

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  • Evidence from RCTs is evaluated for agents currently accepted or proposed as mood stabilizers.
  • Pharmacological actions of established mood stabilizers are analyzed.

    • Conclusions:

    • The evidence base for mood stabilizers in bipolar disorder varies and requires careful evaluation.
    • Understanding pharmacological mechanisms is crucial for defining and developing effective mood stabilizers.