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Androgens and puberty.

Olaf Hiort1

  • 1Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Lübeck, Ratzeburger Allee 160, Lübeck 23538, Germany.

Best Practice & Research. Clinical Endocrinology & Metabolism
|May 4, 2002
PubMed
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Puberty involves rising androgenic steroids from adrenal and gonadal sources, influencing development via the androgen receptor. These hormones drive virilization, anabolism, and spermatogenesis, with biosynthesis and actions discussed.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Reproductive Biology

Background:

  • Puberty is marked by increased androgen production.
  • Adrenal androgenesis (adrenarche) may precede gonadal steroidogenesis.
  • Androgens act through the androgen receptor, a transcription factor.

Purpose of the Study:

  • To discuss the role of different androgenic steroids in puberty.
  • To explore the control of androgen biosynthesis.
  • To examine the differential actions and target organs of androgens.

Main Methods:

  • Review of existing literature on pubertal androgens.
  • Discussion of molecular mechanisms of androgen action.
  • Analysis of hormonal control and gene regulation.

Related Experiment Videos

Main Results:

  • Androgens mediate key pubertal changes: virilization (genital growth, sexual hair) and anabolism (muscle gain, body composition changes).
  • Androgens are crucial for spermatogenesis initiation and maintenance.
  • The androgen receptor modulates transcription of numerous, largely uncharacterized genes.

Conclusions:

  • Androgenic steroids are pivotal during puberty, with distinct roles.
  • Understanding androgen biosynthesis control and differential actions is important.
  • Further research is needed to elucidate androgen-regulated genes and pathways.