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Related Experiment Videos

Gender difference in diastolic function in hypertension (the HyperGEN study).

Jonathan N Bella1, Vittorio Palmieri, Dalane W Kitzman

  • 1Department of Medicine, Cornell Medical Center, New York, New York 10021, USA.

The American Journal of Cardiology
|May 4, 2002
PubMed
Summary

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Men exhibit slower early diastolic left ventricular (LV) filling compared to women, indicated by prolonged deceleration time and isovolumic relaxation time (IVRT). This gender difference in diastolic function may offer insights into cardiovascular diseases.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Medical Research

Background:

  • Gender differences in left ventricular (LV) systolic function are documented.
  • Limited understanding exists regarding gender-specific differences in diastolic function.

Purpose of the Study:

  • To investigate potential gender differences in diastolic function among hypertensive adults.
  • To analyze Doppler echocardiographic parameters related to LV diastolic function in men and women.

Main Methods:

  • Analysis of Doppler echocardiograms from 515 men and 839 women in the Hypertension Genetic Epidemiology Network (HyperGEN) study.
  • Adjustment for age, race, body mass index, heart rate, blood pressure, and LV hypertrophy.
  • Comparison of mitral E-wave, A-wave velocities, E/A ratio, atrial filling fraction, deceleration time, and isovolumic relaxation time (IVRT).

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Main Results:

  • Men had lower body mass index and heart rates, but higher systolic and diastolic blood pressure than women.
  • Mitral E-wave and A-wave velocities were lower in men, while E/A ratio and atrial filling fraction were similar.
  • Men showed significantly longer deceleration time and isovolumic relaxation time (IVRT), with a higher prevalence of prolonged IVRT.

Conclusions:

  • Hypertensive men in this cohort demonstrated slower early diastolic LV filling compared to women.
  • Prolonged deceleration time and IVRT in men suggest impaired diastolic function.
  • These findings may contribute to understanding gender disparities in heart failure and cardiovascular diseases.