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Related Experiment Video

Updated: Jul 6, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Axonal self-destruction and neurodegeneration.

Martin C Raff¹, Alan V Whitmore, John T Finn

¹MRC Laboratory for Molecular Cell Biology and Cell Biology Unit and the Biology Department, University College London, London WC1E 6BT, UK. m.raff@ucl.ac.uk

Science (New York, N.Y.)

|May 4, 2002

Summary

Neurons possess two distinct self-destruct mechanisms. One is apoptosis for cell death, while the second rapidly degenerates severed axons, a process potentially used in development and stress response.

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Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

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Published on: March 16, 2020

Area of Science:

Neurobiology
Cellular Biology
Developmental Neuroscience

Background:

Neurons have intrinsic self-destruct pathways.
Apoptosis is a known cell death mechanism in neurons.

Purpose of the Study:

To investigate the existence and function of a second, distinct neuronal self-destruct program.
To determine if this program is involved in axonal pruning and response to insults.

Main Methods:

The abstract does not specify methods.

Main Results:

Neurons possess at least two self-destruct programs.
A second program exists in the axon, distinct from apoptosis.
This axonal program triggers rapid degeneration of severed axons.

Conclusions:

Neurons have a specialized mechanism for axon self-destruction.
This mechanism may play roles in neural development and response to cellular stress.