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Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study

Daniel Woo1, Laura R Sauerbeck, Brett M Kissela

  • 1Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267-0525, USA. Daniel.woo@uc.edu

Stroke
|May 4, 2002
PubMed

Insights

Genetic and environmental factors influence intracerebral hemorrhage (ICH) risk differently based on location. Apolipoprotein E alleles are linked to lobar ICH, while hypertension is key for nonlobar ICH.

Area of Science:

  • Neurology
  • Epidemiology
  • Genetics

Background:

  • Intracerebral hemorrhage (ICH) presents a high mortality rate (40-50%) with limited treatment options.
  • This study investigates genetic and environmental risk factors for ICH.

Purpose of the Study:

  • To identify significant independent risk factors for lobar and nonlobar intracerebral hemorrhage.
  • To determine the attributable risk of identified factors for different ICH subtypes.

Main Methods:

  • Population-based case-control study involving 188 ICH cases and 366 controls.
  • Prospective identification of stroke cases across 16 hospitals.
  • Multivariable logistic regression analysis to identify independent risk factors.

Main Results:

  • Lobar ICH risk factors: apolipoprotein E2/E4 allele, alcohol use, prior stroke, family history.
  • Nonlobar ICH risk factors: hypertension, prior stroke, family history.
  • Increased education correlated with decreased nonlobar ICH risk.

Conclusions:

  • Pathophysiology of ICH differs significantly by location.
  • Apolipoprotein E alleles account for 29% of lobar ICH; hypertension accounts for 54% of nonlobar ICH.
Abstract

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