Candidate-gene approaches for studying complex genetic traits: practical considerations
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Updated: Aug 14, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Holly K Tabor1, Neil J Risch, Richard M Myers
1Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305-5120, USA.
Abstract:
Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of non-replication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation.
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