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Related Experiment Videos

Micro-receiver guided transcranial beam steering.

Greg T Clement1, Kullervo Hynynen

  • 1Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. gclement@hms.harvard.edu

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
|May 7, 2002
PubMed
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This study explores a novel method for focusing ultrasound energy through the skull for brain therapy. The technique uses a catheter-inserted hydrophone to guide therapeutic ultrasound, enabling precise cell destruction and tissue coagulation.

Area of Science:

  • Neurosurgery
  • Biomedical Engineering
  • Acoustic Physics

Background:

  • Focused ultrasound surgery (FUS) offers non-invasive therapeutic potential.
  • Accurate focusing of ultrasound through the skull remains a challenge due to acoustic aberrations.

Purpose of the Study:

  • To investigate a new method for focusing ultrasound energy in brain tissue through the skull.
  • To test the feasibility and range of this trans-skull ultrasound focusing technique.

Main Methods:

  • Utilized a therapeutic transducer array and a catheter-inserted hydrophone receiver for acoustic guidance.
  • Employed acoustic phase information from the receiver to steer and correct ultrasound beams for skull-induced aberrations.
  • Tested the method with 1.1 MHz and 0.81 MHz transducer arrays on ex vivo human skull models.

Related Experiment Videos

  • Evaluated in vitro application using a hemisphere array for trans-skull surgery, targeting tissue coagulation.

    • Main Results:

    • Achieved focal intensities of several hundred watts per centimeter-squared, capable of destroying cells.
    • Demonstrated reconstruction and steering of ultrasound focus over a 50 mm distance using specific array configurations.
    • Successfully achieved tissue coagulation at a depth of 10 mm from the receiver in an in vitro skull model.

    Conclusions:

    • The developed method shows feasibility for trans-skull ultrasound focusing.
    • The technique allows for electronic steering and aberration correction, crucial for therapeutic applications.
    • This minimally invasive approach holds promise for future ultrasound brain therapy and surgery.