Related Experiment Video
Updated: Oct 1, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
Syntheses, chemical and enzymatic stability of new poly(ethylene glycol)-acyclovir prodrugs
M Zacchigna1, G Di Luca, V Maurich
1Department of Pharmaceutical Sciences, University of Trieste, Italy. zacchign@univ.trieste.it
Abstract:
Two known antiherpetic agents, acyclovir and valaciclovir, were coupled with activated poly(ethylene glycol). In vitro drug release studies demonstrated the conjugates to be stable in buffer solutions at pH 7.4 and 5.5, while only PEG-valacyclovir2 was stable in a buffer solution at pH 1.2. The ability of the macromolecular conjugate to release the free drug was also evaluated in plasma, in which the most stable prodrug also proved to be PEG-valacyclovir2. The derivatives are degraded in the presence of proteolytic enzyme. The rate of hydrolysis was monitored by HPLC-analysis.
More Related Videos
08:46Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
Published on: July 26, 2018
11:32Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
Published on: December 23, 2013
Related Concept Videos
Antiviral Nucleoside Inhibitors
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
DNA Base Pairing
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Prodrugs
Prodrugs help overcome...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention