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Further studies on the interaction of Toxoplasma gondii with neutrophils and eosinophils
1Laboratory of Cellular Ultrastructure Hertha Meyer, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Brazil.
Journal of Submicroscopic Cytology and Pathology
|May 7, 2002
Abstract:
Tachyzoites of Toxoplasma gondii are ingested by neutrophils and eosinophils through a process which can be significantly inhibited by previous incubation of the host cells with cytochalasin D. Although dividing zoites within the leukocytes could be observed, after 3 h of infection, killing of parasites within the parasitophorous vacuole was detected. Cytochemical studies showed that both in neutrophils and eosinophils there is a process of NADP(H) oxidase activation, which was higher in the latter.