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Isobolographic analysis of interaction between vigabatrin and baclofen in the formalin test in mice
M Czuczwar1, J Kiś, A Potasiński
1Second University Department of Anesthesiology and Intensive Therapy, Medical University, Lublin, Poland.
Polish Journal of Pharmacology
|May 7, 2002
Abstract:
Vigabatrin and baclofen given together, at doses not affecting motor performance, produced dose-dependent inhibition of both phases in the formalin test in mice. Isobolographic analysis revealed a significant synergy between both drugs in both phases of the forrmalin test.