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Related Experiment Videos

Forced expiratory time and bronchial hyperresponsiveness to methacholine.

Marc F Goldstein1, Bernadette A Veza, Arlene Lauf-Goldstein

  • 1Department of Medicine and Pediatrics, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, USA. gpike@aol.com

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|May 7, 2002
PubMed
Summary

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Shortened forced expiratory times (FET100%) in baseline pulmonary function tests (PFTs) correlate with positive methacholine inhalation challenges (MICs) in suspected asthma patients. FET100% <4 seconds indicates a higher likelihood of a positive MIC.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Pulmonary function tests (PFTs) typically precede methacholine inhalation challenges (MICs).
  • Abnormal baseline forced expiratory times (FET100%) have been observed in patients with positive MICs, contrary to normal spirometry (FEV1, FEF25%-27%, FVC).

Purpose of the Study:

  • To prospectively evaluate the correlation between abnormalities in baseline pre-MIC FET100% and positive versus negative MIC results.
  • To determine if FET100% can predict a positive MIC in individuals suspected of having asthma.

Main Methods:

  • Prospective analysis of baseline pre-MIC FET100% and MIC results in patients with suspected asthma, normal lung exams, spirometry, and chest X-rays.
  • Used a PC20 FEV1 threshold of ≤8mg/ml methacholine to define positive and negative MICs.
  • Compared mean FET100% and incidence of FET100% <4 seconds between positive (n=115) and negative (n=69) MIC groups.

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Main Results:

  • The mean FET100% was significantly shorter in the positive MIC group (3.57±1.68 sec) compared to the negative group (4.73±1.60 sec) (p <0.0001).
  • A significantly higher incidence of FET100% <4 seconds was found in the positive MIC group (55.65%) versus the negative group (30.43%) (p<0.001).
  • Positive MICs were significantly more frequent in patients with FET100% <4 seconds (75.29%) compared to those with FET100% ≥4 seconds (51.52%) (p<0.001).

Conclusions:

  • Shortened baseline FET100% <6 seconds is common in this patient population.
  • A baseline FET100% <4 seconds strongly correlates with an increased likelihood of a positive methacholine inhalation challenge.
  • FET100% may serve as a useful predictive marker for bronchial hyperresponsiveness.