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Related Concept Videos

Genetic Lingo01:11

Genetic Lingo

Overview
Pedigree Analysis01:35

Pedigree Analysis

Overview
Test Cross01:39

Test Cross

Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...

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Related Experiment Video

Updated: Jun 18, 2026

Whole-mount Imaging of Mouse Embryo Sensory Axon Projections
08:37

Whole-mount Imaging of Mouse Embryo Sensory Axon Projections

Published on: December 9, 2014

A case of Ax phenotype transmitted by an A2B parent.

J Ducos, Y Marty, J Ruffie

    Vox Sanguinis
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    In this family study, the Ax gene behaved like A2 when located next to the B gene. This finding clarifies the phenotypic expression of blood group genes in specific genetic arrangements.

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    Last Updated: Jun 18, 2026

    Whole-mount Imaging of Mouse Embryo Sensory Axon Projections
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    Published on: December 9, 2014

    Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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    In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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    Area of Science:

    • Genetics
    • Immunology
    • Molecular Biology

    Background:

    • Understanding the complex interactions of ABO blood group alleles is crucial for genetic studies.
    • The phenotypic expression of blood group genes can be influenced by their genetic context.

    Purpose of the Study:

    • To investigate the inheritance patterns and phenotypic expression of blood group alleles within a specific family.
    • To determine the influence of the B gene on the expression of the Ax allele.

    Main Methods:

    • Pedigree analysis of blood group phenotypes within a multi-generational family.
    • Genotyping and phenotyping of family members to determine ABO blood group status.

    Main Results:

    • The family exhibited a complex inheritance pattern with Ax, B, and A2B phenotypes observed.
    • A key finding was that the Ax gene, when in a 'trans' position relative to the B gene, presented phenotypically as A2.
    • Offspring from an A2B individual married to an O individual showed an Ax phenotype, further supporting the gene interaction.

    Conclusions:

    • The Ax allele's phenotypic expression is context-dependent, influenced by neighboring alleles.
    • The presence of the B allele can mask or alter the typical expression of the Ax allele, leading to an A2-like phenotype.
    • This study provides valuable insights into the complexities of ABO blood group genetics and allele interactions.