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Related Experiment Videos

Plummer Vinson syndrome: unusual features.

Govind K Makharia1, Bhaskar Nandi, Pramod K Garg

  • 1Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|May 7, 2002
PubMed
Summary

Plummer Vinson syndrome, a rare disorder, typically presents with esophageal webs and iron deficiency anemia. This study highlights unusual patient manifestations, including clubbing and celiac disease, expanding the known clinical spectrum.

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Area of Science:

  • Gastroenterology
  • Hematology
  • Internal Medicine

Background:

  • Plummer Vinson syndrome (PVS) is characterized by postcricoid esophageal webs, iron deficiency anemia, and dysphagia.
  • Koilonychia (spoon-shaped nails) is a classic but not universal sign.
  • Understanding PVS variations is crucial for accurate diagnosis and management.

Observation:

  • This report details three PVS patients with atypical clinical presentations.
  • Manifestations included digital clubbing instead of koilonychia.
  • Esophageal tortuosity was observed alongside the characteristic webs.

Findings:

  • One patient presented with coexisting celiac disease, a previously underreported association.
  • The study expands the recognized phenotypic variability of Plummer Vinson syndrome.

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  • These findings underscore the importance of thorough patient evaluation.

    • Implications:

    • Recognizing these unusual signs can aid in earlier PVS diagnosis.
    • The association with celiac disease warrants further investigation.
    • This broadens the differential diagnosis for patients with dysphagia and anemia.