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Updated: Aug 8, 2026

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells
Published on: July 22, 2013
The mitochondrial antioxidant defence system and its response to oxidative stress
T Rabilloud1, M Heller, M P Rigobello
1CEA-Laboratoire de Bioénergétique Cellulaire et Pathologique, DBMS/BECP, CEA-Grenoble, France. Thierry@sanrafael.ceng.cea.fr
Abstract:
The antioxidant systems of mitochondria are not well known. Using a proteomics-based approach, we defined these mitochondrial antioxidant systems and analyzed their response to oxidative stress. It appears that the major mitochondrial antioxidant system is made of manganese superoxide dismutase on the one hand, and of peroxiredoxin III, mitochondrial thioredoxin and mitochondrial thioredoxin reductase on the other hand. With the exception of thioredoxin reductase, all these proteins are induced by oxidative stress. In addition, a change in the peroxiredoxin III pattern can also be observed.
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