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New functions for the matrix metalloproteinases in cancer progression

  • 0Department of Anatomy, University of California at San Francisco, 94143-0452, USA. egeblad@itsa.ucsf.edu
Nature Reviews. Cancer +

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May 7, 2002

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May 7, 2002

View abstract on PubMed

Summary

This summary is machine-generated.

Matrix metalloproteinases (MMPs) are linked to cancer spread, but inhibitors failed clinically. Rethinking MMP inhibitor use is needed, considering their broader roles in early cancer development beyond invasion.

Area Of Science

  • Oncology
  • Biochemistry
  • Cancer Biology

Background

  • Matrix metalloproteinases (MMPs) were historically linked to cancer invasion and metastasis.
  • Clinical trials of MMP inhibitors yielded disappointing outcomes.
  • Emerging evidence reveals MMPs have roles beyond invasion and extracellular matrix degradation.

Purpose Of The Study

  • To re-evaluate the therapeutic potential of MMP inhibitors in cancer treatment.
  • To explore the multifaceted roles of MMPs in cancer development.
  • To consider MMP functions preceding cancer cell invasion.

Main Methods

  • Review of existing literature on MMP functions in cancer.
  • Analysis of novel substrates and roles of MMPs.
  • Correlation of MMP activity with early cancer development stages.

Main Results

  • MMPs possess diverse functions beyond promoting cancer cell invasion.
  • MMPs interact with substrates other than extracellular matrix components.
  • MMP activity is implicated in cancer development prior to metastatic stages.

Conclusions

  • The established role of MMPs in cancer necessitates a revised therapeutic strategy.
  • MMP inhibitors may require re-evaluation for clinical application based on their broader functions.
  • Targeting MMPs at different stages of cancer development could offer new therapeutic avenues.

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