Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

APOE genotypes and disease severity in multiple sclerosis.

T Masterman1, Z Zhang, D Hellgren

  • 1Division of Neurology, NEUROTEC, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden. thomas.masterman@neurotec.ki.se

Multiple Sclerosis (Houndmills, Basingstoke, England)
|May 7, 2002
PubMed
Summary

The apolipoprotein E (APOE) epsilon4 allele does not affect multiple sclerosis (MS) risk but may influence disease progression. This study found no significant genotype differences between benign and severe MS groups.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Big multiple sclerosis data network: novel modelling approaches for real-world data analysis.

Journal of neurology·2025
Same author

Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils.

Aging brain·2023
Same author

Season of birth is associated with multiple sclerosis and disease severity.

Multiple sclerosis journal - experimental, translational and clinical·2022
Same author

Neurofilament light chain as a marker for cortical atrophy in multiple sclerosis without radiological signs of disease activity.

Journal of internal medicine·2021
Same author

Stressful life events are associated with the risk of multiple sclerosis.

European journal of neurology·2020
Same author

Clinical course of multiple sclerosis and labour-force absenteeism: a longitudinal population-based study.

European journal of neurology·2018

Area of Science:

  • Neuroimmunology
  • Genetics
  • Neurodegenerative Diseases

Background:

  • Apolipoprotein E (APOE) plays a role in lipid transport and membrane repair.
  • The APOE epsilon4 allele is linked to Alzheimer's disease susceptibility and poorer outcomes in other neurological conditions.
  • Previous research suggests APOE epsilon4 does not increase MS risk but may impact disease progression.

Purpose of the Study:

  • To investigate the association between APOE genotypes and disease severity in multiple sclerosis (MS).
  • To compare APOE epsilon2-4 genotypes in patients with benign MS versus severe MS.
  • To determine if APOE epsilon4 influences the rate of disability accumulation in MS.

Main Methods:

  • Genotyping of APOE epsilon2-4 alleles in a cohort of over 900 MS patients.

Related Experiment Videos

  • Comparison of genotype frequencies between the least disabled (benign MS, EDSS ≤ 3.0 after 10 years) and most disabled (severe MS, EDSS ≥ 6.0 within 8 years) patient groups.
  • Analysis of APOE genotype and phenotype frequencies in relation to disease duration and disability scores.

    • Main Results:

    • No significant differences in APOE genotype or phenotype frequencies were observed between the benign MS and severe MS groups.
    • The risk associated with the APOE epsilon4 allele appeared to increase when comparing more narrowly defined, extreme quantiles of disease severity.
    • The study did not find a direct correlation between specific APOE genotypes and the defined categories of benign or severe MS.

    Conclusions:

    • APOE epsilon4 carriage is not significantly associated with distinct benign or severe multiple sclerosis phenotypes based on the studied definitions.
    • While not a primary risk factor for MS development, the APOE epsilon4 allele's influence on disease progression warrants further investigation, particularly in extreme disability groups.
    • The findings suggest a complex interplay between APOE genetics and MS disease course that requires more nuanced analysis beyond broad disability categories.