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Related Experiment Videos

Brain ageing in the new millennium.

J N Trollor1, M J Valenzuela

  • 1School of Psychiatry, University of New South Wales and Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia. michaelv@unsw.edu.au

The Australian and New Zealand Journal of Psychiatry
|May 7, 2002
PubMed
Summary

Brain ageing involves specific structural and functional changes, but global cognitive decline is not typical. Research is exploring molecular mechanisms and protective factors to understand and potentially mitigate age-related cognitive changes.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Science

Background:

  • The ageing process significantly impacts brain structure and function.
  • Understanding age-related brain changes is crucial for addressing cognitive health.

Purpose of the Study:

  • To review current literature on brain ageing.
  • To provide an overview of age-related structural and functional brain changes.
  • To examine potential mediators of these changes.

Main Methods:

  • A comprehensive MEDLINE search was performed.
  • Relevant articles were selectively reviewed.

Main Results:

  • Global cognitive decline is not a hallmark of ageing; however, fluid intellectual abilities may decline.

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  • Regionally specific structural and functional changes occur, observable via neuroimaging.
  • Neuronal number remains stable, except in certain hippocampal regions; molecular mechanisms are under investigation.
  • Factors like 'brain reserve,' neuroprotective agents, and hormonal influences are being studied for their protective roles.

    • Conclusions:

    • Understanding the biological basis of ageing is advancing.
    • This knowledge aids in comprehending vulnerability to age-associated neuropsychiatric diseases.