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Updated: Oct 1, 2026
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A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors
Chi Choi1, Jia-He Li, Mark Vaal
1Guilford Pharmaceuticals Inc., Research Department, 6611 Tributary Street, Baltimore, MD 21224, USA.
Bioorganic & Medicinal Chemistry Letters
|May 7, 2002
Abstract:
Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series.
