Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Donor hepatic function: a factor in postreperfusion syndrome.

Rocco Ricciardi1, David P Foley, Steven H Quarfordt

  • 1Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA. rocco.ricciardi@umassmed.edu

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
|May 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypertrophic cauda equina syndrome in mycobacterial meningoradiculitis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

The dominant role of geriatrics vulnerabilities and comorbidities in readmissions after colorectal surgery: Shifting from "nonmodifiable" to "actionable" risk.

Surgery·2026
Same author

Portal-Venous Hypothermic Oxygenated Perfusion for Liver Transplant: A Randomized Clinical Trial.

JAMA surgery·2026
Same author

Delay in Surgical Fixation of Operatively Treated Thoracolumbar Fractures in the Elderly Associated With Minimal Increase in Short-Term Complications.

Global spine journal·2026
Same author

Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects.

Nature biomedical engineering·2026
Same author

ECG-Based Deep Learning Estimation of VO2 Prognosticates Outcomes in Colorectal Surgery.

European journal of preventive cardiology·2026
Same journal

Minimizing chronic groin pain after inguinal hernia surgery: An augmented evidence review.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Beyond Incontinence: A Systematic Review and Meta-Analysis of Sexual Dysfunction after Anal Fistula Surgery.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Intracorporeal Wide V-Shaped Esophagojejunostomy During Minimally Invasive Total Gastrectomy: A Novel Reconstructive Technique.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Redefining textbook outcome in contemporary colon surgery.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Clinical impact of underlying end-stage renal disease in patients undergoing resection for hepatic malignancy.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Invited Commentary on: Thoracic Duct Identification using Indocyanine Green Fluorescence (ICG) in Robotic Esophagectomy.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
See all related articles

Optimally functioning support livers improve recipient hemodynamics during extracorporeal liver perfusion. Poor support liver function negatively impacts recipient liver function and hemodynamic stability.

Area of Science:

  • Transplantation immunology
  • Surgical research
  • Organ preservation

Background:

  • Postreperfusion syndrome is a common complication during liver transplantation and extracorporeal perfusion.
  • The functional status of a cold-preserved support liver can impact recipient outcomes.

Purpose of the Study:

  • To evaluate the influence of a cold-preserved porcine support liver on recipient hemodynamics and in situ liver function during extracorporeal perfusion.
  • To correlate support liver function parameters with recipient hemodynamic and hepatic parameters.

Main Methods:

  • Porcine support livers were cold-preserved and reperfused in an extracorporeal circuit with healthy recipient pigs.
  • Correlation analyses were performed between support liver function (oxygen consumption, bile flow, biliary lipid output) and recipient hemodynamics (heart rate, blood pressure, urine output, vasopressor use) and liver function (bile flow, biliary phospholipid secretion).

Related Experiment Videos

Main Results:

  • Optimally functioning support livers correlated with improved recipient hemodynamic stability, indicated by decreased heart rate and vasopressor use, and increased urine output.
  • Support livers with poor biliary secretory function were associated with diminished recipient liver biliary secretory function.
  • Support liver function directly impacts recipient hemodynamic and hepatic parameters.

Conclusions:

  • The functional state of a cold-preserved support liver significantly influences recipient hemodynamic stability.
  • Support liver biliary secretory function is a key indicator of its potential impact on recipient liver function.
  • Maintaining optimal support liver function is crucial for improving outcomes in liver perfusion and transplantation procedures.