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In vitro fertilization. The Jamaican experience.
J Frederick1, S Wynter, V DaCosta
1Department of Obstetrics, Gynaecology and Child Health, University of the West Indies, Kingston 7, Jamaica.
The West Indian Medical Journal
|May 8, 2002
Summary
This study reports successful initial in vitro fertilization (IVF) outcomes for infertile couples, achieving a 20.8% pregnancy rate with controlled ovarian hyperstimulation. The program also managed ovarian hyperstimulation syndrome (OHSS) cases effectively.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization
- Endocrinology
Background:
- Assisted reproductive technologies aim to help infertile couples conceive.
- Controlled ovarian hyperstimulation is a key component of in vitro fertilization (IVF) protocols.
- Establishing new fertility programs requires careful monitoring and evaluation of initial outcomes.
Purpose of the Study:
- To evaluate the efficacy and safety of an initial in vitro fertilization (IVF) program.
- To assess pregnancy rates and the incidence of ovarian hyperstimulation syndrome (OHSS) in a new assisted reproduction program.
- To establish a benchmark for future IVF treatments at the Fertility Management Unit.
Main Methods:
- Twenty-eight infertile couples underwent IVF and embryo transfer.
- Pre-treatment criteria included specific follicle-stimulating hormone (FSH) and oestradiol (E2) levels.
- Down-regulation used buserelin acetate, followed by ovarian hyperstimulation with pergonal.
Main Results:
- A total of 294 oocytes were retrieved, with 138 fertilized.
- Five patients (20.8%) achieved positive pregnancy tests.
- Three patients (0.1%) experienced ovarian hyperstimulation syndrome (OHSS), all successfully treated.
Conclusions:
- The initial IVF program demonstrated promising success rates for infertile couples.
- Controlled ovarian hyperstimulation protocols can be safely implemented with effective OHSS management.
- These positive outcomes support the future potential of the Fertility Management Unit.