Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Postischemic reperfusion injury. Biochemical and methodological principles].

H J Brömme1, H Loertzer, Z Akçetin

  • 1Institut für Pathophysiologie der Martin-Luther-Universität Halle-Wittenberg, Magdeburger Strasse 18, 06097 Halle/Saale. h-j.broemme@medizin.uni-halle.de

Der Urologe. Ausg. A
|May 8, 2002
PubMed
Summary

Ischemic reperfusion injury involves cell damage during ischemia and reoxygenation, impacting organ survival. Understanding reactive oxygen intermediate (ROI) mechanisms is key to minimizing kidney damage and preserving function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of adjustable male slings and artificial urinary sphincter in the treatment of male urinary incontinence: a retrospective analysis of patient selection and postoperative continence status.

World journal of urology·2018
Same author

[Stress incontinence in elderly women].

Der Urologe. Ausg. A·2013
Same author

[Prolapse surgery. With abdominal or vaginal meshes?].

Der Urologe. Ausg. A·2012
Same author

[Intermittent androgen deprivation as therapy for androgen-sensitive prostate cancer. Sense or nonsense?].

Der Urologe. Ausg. A·2012
Same author

[Pyeloplasty - pro robotic-assisted].

Der Urologe. Ausg. A·2012
Same author

[Laser now also to be used in organ-preserving kidney surgery?].

Der Urologe. Ausg. A·2012

Area of Science:

  • Biomedical Science
  • Cellular Biology
  • Organ Transplantation

Context:

  • Ischemic reperfusion injury (IRI) is a critical factor affecting organ survival, particularly in kidney transplantation.
  • Reactive oxygen intermediates (ROI) are significantly involved in the cellular damage occurring during post-ischemic reperfusion.
  • Understanding IRI mechanisms is essential for improving transplant outcomes.

Purpose:

  • To elucidate the fundamental mechanisms of reactive oxygen intermediate (ROI) generation and detoxification during ischemic reperfusion injury (IRI).
  • To demonstrate methods for the registration and quantification of ROI in rat kidneys experiencing IRI.
  • To provide a basis for developing cytoprotective strategies against IRI.

Summary:

  • This report details the cellular toxic events associated with ischemic reperfusion injury (IRI), focusing on the role of reactive oxygen intermediates (ROI).

Related Experiment Videos

  • It explores the generation, detoxification, and measurement of ROI in the context of IRI in rat kidneys.
  • The study highlights the importance of understanding these mechanisms for preserving organ function.

    • Impact:

    • Provides foundational knowledge for developing novel cytoprotective therapies to mitigate IRI.
    • Aims to improve organ survival rates in transplantation by minimizing ischemia-reperfusion related damage.
    • Contributes to the broader understanding of cellular stress responses and organ preservation techniques.