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Updated: Jul 14, 2026
06:34
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Cinecoronary arteriography in young men
C C Welch1, W L Proudfit, F M Sones
1Department of Clinical Cardiology, Department of Cardiovascular Disease and Cardiac Laboratory, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Circulation
|October 1, 1970
Summary
Coronary artery disease is prevalent in men under 40, with nearly half showing significant narrowing. Cholesterol levels strongly correlate with the presence and severity of coronary artery lesions.
Area of Science:
- Cardiology
- Vascular Medicine
- Diagnostic Imaging
Background:
- Coronary artery disease (CAD) is typically associated with older populations.
- Younger individuals experiencing chest pain often undergo diagnostic evaluation for CAD.
Purpose of the Study:
- To investigate the prevalence and characteristics of coronary artery narrowing in men under 40 years old.
- To correlate angiographic findings with clinical symptoms, electrocardiographic (ECG) results, and cholesterol levels.
Main Methods:
- Cinecoronary arteriography was performed on 723 men under 40 presenting with chest pain.
- Analysis included lesion distribution, severity, and correlation with ECG, left ventriculograms, and serum cholesterol.
Main Results:
- 49% of the men had significant coronary artery narrowing (≥50%).
- The anterior descending artery was most frequently affected; the right coronary artery showed the most total occlusions.
- Higher cholesterol levels (>275 mg/100 ml) were associated with a significantly higher prevalence of CAD (81%) compared to lower levels (<200 mg/100 ml, 20%).
Conclusions:
- Significant coronary artery narrowing is common in young men evaluated for chest pain.
- Cholesterol levels are a key indicator of CAD risk in this demographic.
- Angiographic findings correlate well with clinical diagnoses, especially in typical presentations.
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