Related Experiment Video
Updated: Jul 30, 2026

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
Published on: February 3, 2021
[Taking history in diagnosing coronary artery disease in the 21st century--wasting time or a valuable diagnostic
M Lewandowski1, H Szwed, I Kowalik
1Klinika Choroby Wieńcowej Instytutu Kardiologii w Warszawie.
Insights
Chest pain characteristics effectively estimate the probability of coronary artery disease (CAD). This study in 551 patients with stable angina confirms the diagnostic value of symptom assessment in identifying significant coronary narrowing.
Area of Science:
- Cardiology
- Diagnostic Medicine
Background:
- Stable angina pectoris presents diagnostic challenges.
- Coronary artery disease (CAD) requires accurate identification.
Purpose of the Study:
- To assess the relationship between chest pain characteristics and coronary angiogram findings.
- To evaluate the utility of patient history in diagnosing CAD.
Main Methods:
- A standardized questionnaire collected demographic and chest pain data from 551 patients.
- Pain was classified as typical, atypical, or nonanginal using the Diamond classification.
- Diagnostic coronary angiography was performed to define clinically significant CAD (>50% vessel narrowing).
Main Results:
- Chest pain characteristics were correlated with the presence and severity of coronary artery disease.
- The study identified specific historical features predictive of significant coronary narrowing.
Conclusions:
- Patient-reported chest pain characteristics remain a valuable tool for estimating the likelihood of coronary artery disease.
- Symptom analysis aids in the non-invasive assessment of stable angina patients prior to invasive procedures.
Unlabelled:
The relation of chest pain characteristics and other features of the history of disease to coronary angiograms was assessed in 551 patients with chest pain regarded as definite or probable stable angina pectoris. A standardised questionnaire was used to record demographic details and chest pain characteristics of interviewed patients. The differentiation between typical, atypical or nonanginal pain was based on classification proposed by Diamond. The indications for catheterization in each patient were determined at the discretion of the attending physician. All patients underwent diagnostic coronary angiography (clinically important coronary artery disease was defined as > 50 per cent narrowing of the diameter of at least one major vessel or > or = 50 per cent of the left main coronary artery).
Conclusion:
Chest pain characteristics remains an effective tool for estimating probability of coronary artery disease.
More Related Videos
Related Concept Videos
Imaging Studies for Cardiovascular System V: CT
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Coronary Artery Disease I: Introduction
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome III: Diagnostic Studies
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

