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Migraine and the extrapyramidal system.

P Barbanti1, G Fabbrini

  • 1Department of Neurological Sciences, University La Sapienza, Rome, Italy. piero.barbanti@uniroma1.it

Cephalalgia : an International Journal of Headache
|May 8, 2002
PubMed
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This review suggests the extrapyramidal system (EPS) is involved in migraine, potentially in pain processing or adaptive responses. However, direct primary involvement in migraine pathophysiology remains unproven.

Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Migraine is a complex neurological disorder.
  • The extrapyramidal system (EPS) is involved in motor control and other functions.
  • The relationship between migraine and the EPS is not fully understood.

Purpose of the Study:

  • To review and critically appraise existing clinical and experimental data on the interactions between migraine and the EPS.
  • To evaluate the evidence for the EPS's role in migraine pathophysiology.

Main Methods:

  • Systematic review of clinical and experimental studies.
  • Critical appraisal of observational data.
  • Analysis of shared neurotransmitters and pathways.

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Main Results:

  • The EPS appears to be involved in migraine.
  • Concomitant occurrence of migraine and EPS symptoms/diseases suggests a link.
  • Shared neurotransmitters and pathways between migraine and EPS are noted.

Conclusions:

  • Direct primary involvement of the EPS in migraine pathophysiology is not yet proven.
  • EPS involvement in migraine may relate to nociceptive processing.
  • EPS involvement could be part of migraine's adaptive behavioral response.