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Mobius sequence--a Swedish multidiscipline study.

Kerstin Strömland1, Lotta Sjögreen, Marilyn Miller

  • 1Department of Ophthalmology, Göteborg University, Sweden. kerstin.stromland@oft.gu.se

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|May 8, 2002
PubMed
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Mobius sequence, a rare disorder affecting cranial nerves, often presents with limb malformations, speech issues, and eating difficulties. A significant portion of patients also exhibit autism and mental retardation, highlighting the syndrome's complex nature.

Area of Science:

  • Neurology
  • Genetics
  • Pediatrics

Background:

  • Mobius sequence is a rare congenital disorder primarily affecting the 6th and 7th cranial nerves.
  • It can involve other cranial nerves, skeletal and orofacial anomalies, and intellectual disability.

Purpose of the Study:

  • To determine the frequency of clinical characteristics associated with Mobius sequence.
  • To identify potential pregnancy or environmental factors in affected patients.

Main Methods:

  • A prospective study involving 25 Swedish patients with apparent 6th and 7th cranial nerve involvement.
  • Examination of 25 patients aged 1 month to 55 years.

Main Results:

  • Associated anomalies included limb malformations (10), Poland anomaly (2), hypodontia (7), microglossia (6), cleft palate (4), hearing impairment (5), and external ear malformation (1).

Related Experiment Videos

  • Functional issues involved facial expression (16), speech (13), eating/swallowing (12), and infant sucking difficulties (11).
  • Autism or autistic-like conditions were present in 7 patients, and all patients had mental retardation.

    • Conclusions:

    • Mobius sequence often leads to multiple eating and communication problems due to facial palsy, cleft palate, and tongue anomalies.
    • Autism and mental retardation are diagnosed in one-third of patients.
    • Recognizing the broad spectrum of Mobius sequence manifestations aids in identifying associated issues for improved patient care.