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Which strategy for pertussis vaccination today?

Dorota Z Girard1

  • 1Department of Economics, University of Nantes, LEN-CEBS, Nantes, France. girard@sc-eco.univ-nantes.fr

Paediatric Drugs
|May 8, 2002
PubMed
Summary

Pertussis (whooping cough) vaccination strategies vary globally due to vaccine efficacy, coverage, and public acceptance. National programs must adapt to local pertussis epidemiology and resources for effective control.

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Area of Science:

  • * Public Health and Epidemiology
  • * Vaccinology and Immunology

Background:

  • * Pertussis (whooping cough) remains a significant public health concern, causing infant and child morbidity and mortality.
  • * Global vaccination programs for pertussis have evolved significantly since the 1940s, with national strategies influenced by vaccine characteristics and public perception.

Purpose of the Study:

  • * To analyze the factors influencing national pertussis vaccination program variations.
  • * To examine the impact of whole-cell versus acellular pertussis vaccines on disease incidence and public health.
  • * To discuss the challenges in defining a universal vaccination strategy.

Main Methods:

  • * Comparative analysis of national vaccination policies and pertussis incidence data.
  • * Review of historical trends in pertussis epidemiology and vaccine use.
  • * Examination of factors such as vaccine efficacy, tolerability, coverage, and public acceptance.

Main Results:

  • * Divergent national approaches to whole-cell pertussis vaccines in the 1970s correlated with changes in pertussis incidence.
  • * The re-emergence of pertussis in the 1990s highlighted the importance of booster doses and the role of acellular vaccines.
  • * Differences in acellular vaccine adoption for primary immunization exist, exemplified by the US and UK.

Conclusions:

  • * A single worldwide pertussis vaccination strategy is challenging due to epidemiological and local variations.
  • * National vaccination programs must be tailored to specific epidemiological situations, historical context, and available healthcare resources.
  • * The choice between whole-cell and acellular vaccines for primary immunization requires careful consideration of national factors.

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