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Related Experiment Videos

Nickel contact hypersensitivity in children.

Nanette B Silverberg1, Jonah Licht, Suzanne Friedler

  • 1Department of Dermatology, St. Luke's-Roosevelt Hospital Center, New York, New York, USA. Nsilverberg@slrhc.org

Pediatric Dermatology
|May 8, 2002
PubMed
Summary

Nickel allergy is increasing, affecting 14.3% of North Americans. Early patch testing for nickel allergy is recommended, especially for children with dermatitis or family history, to enable timely nickel avoidance.

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Area of Science:

  • Dermatology
  • Allergology
  • Pediatrics

Background:

  • Nickel allergic contact dermatitis (NACD) is the most prevalent allergy in North America, with a 14.3% incidence.
  • NACD incidence has risen from 10% a decade ago, presumed due to increased environmental nickel exposure, particularly from costume jewelry and belt buckles.
  • Pediatric patients with a history of umbilical or wrist dermatitis, or a family history of NACD, were studied.

Purpose of the Study:

  • To investigate the prevalence and predictors of nickel allergy in pediatric patients.
  • To evaluate the utility of patch testing in identifying nickel allergy in at-risk children.
  • To inform early nickel avoidance strategies for children, especially those with atopic dermatitis.

Main Methods:

  • A cohort of 30 pediatric patients with a history of dermatitis or family history of NACD underwent patch testing with nickel sulfate 5%.

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  • Presence of id reactions and the nature of patch test reactions (papular) were recorded.
  • Statistical analysis was performed to identify predictors of NACD.

    • Main Results:

    • All 30 pediatric patients exhibited positive patch tests to nickel sulfate.
    • Fifty percent of patients experienced an id reaction, with papular reactions consistent with their patch tests.
    • A positive family history of NACD was identified as a potential positive predictor for developing the allergy.

    Conclusions:

    • Patch testing for nickel allergy is highly effective in pediatric patients with umbilical dermatitis and id reactions.
    • Family history may predict the development of NACD, highlighting the importance of nickel avoidance in atopic children.
    • Early identification of nickel reactivity enables timely intervention and nickel avoidance, crucial for managing this prevalent allergy.