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Enhanced monocyte tissue factor expression in hepatosplenic schistosomiasis
1Haematology Department, Theodore Bilharz Research Institute, Giza, Egypt. aliaaamer@yahoo.com
Summary
Patients with hepatosplenic Schistosomiasis show increased monocyte tissue factor (TF) expression, indicating a prothrombotic state. This heightened TF expression is linked to thrombin generation and disease severity, especially during bleeding episodes.
Area of Science:
- Hematology
- Infectious Diseases
- Pathophysiology
Background:
- Hepatosplenic Schistosomiasis is a chronic parasitic disease.
- Hemostatic abnormalities and a prothrombotic state are suspected in this condition.
Purpose of the Study:
- To investigate monocyte tissue factor (TF) expression and activity in patients with hepatosplenic Schistosomiasis.
- To assess the relationship between TF expression, thrombin generation, and disease severity.
Main Methods:
- Monocyte tissue factor (TF) antigen and activity were measured in 67 patients and 15 controls.
- In vitro stimulation with lipopolysaccharide (LPS) was used.
- Prothrombin fragment 1 + 2 (F1 + 2) was measured as a marker of thrombin generation.
Main Results:
- All patient groups exhibited significantly higher monocyte TF antigen and activity compared to controls.
- TF expression was most pronounced during acute variceal bleeding.
- Elevated F1 + 2 levels indicated increased in vivo thrombin generation across disease stages.
Conclusions:
- Monocytes play a significant role in the prothrombotic state associated with hepatosplenic Schistosomiasis.
- Enhanced monocyte TF expression contributes to the hemostatic diathesis observed in the disease.