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Related Experiment Video

Updated: Jun 23, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

Primary cellular immunodeficiencies.

Rebecca H Buckley¹

¹Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

The Journal of Allergy and Clinical Immunology

|May 8, 2002

Summary

Genetic defects in T-cell function cause severe infections in infants, often proving fatal. Early diagnosis through cord blood screening and advanced treatments like gene therapy are crucial for survival.

Area of Science:

Immunology
Genetics
Pediatrics

Background:

T-cell immunodeficiencies present with severe infections, often in infancy.
These conditions are more critical than isolated antibody deficiencies.
Survival is limited without timely intervention.

Purpose of the Study:

To review the spectrum and molecular causes of T-cell defects.
To emphasize the importance of early diagnosis and treatment.
To highlight the role of genetic understanding in patient management.

Main Methods:

Review of current literature on T-cell immunodeficiencies.
Discussion of diagnostic approaches including cord blood screening.
Overview of emerging therapeutic strategies.

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Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production

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Published on: May 31, 2020

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Last Updated: Jun 23, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

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Published on: March 17, 2014

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

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Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production

Published on: May 31, 2020

Main Results:

T-cell defects range from absent function (SCID) to partial deficiency.
Molecular discoveries are expanding the understanding of these disorders.
Early detection via screening is feasible.

Conclusions:

Early recognition of T-cell defects is vital for effective treatment.
Treatments include immunoglobulin replacement, transplantation, and gene therapy.
Molecular definition is key for genetic counseling and prenatal diagnosis.