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Related Experiment Videos

Intravascular lymphomatosis.

Melina E Oei1, George H Kraft1, Harvey B Sarnat2

  • 1Department of Rehabilitation Medicine, University of Washington Medical Center, Seattle, Washington, USA.

Muscle & Nerve
|May 8, 2002
PubMed
Summary

Early diagnosis of intravascular lymphomatosis (IVL), a rare cancer, is possible. This case highlights how electrodiagnostic findings can lead to early detection and successful treatment, improving survival and neurological function.

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Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Intravascular lymphomatosis (IVL), also known as endovascular lymphoma or angiotropic large cell lymphoma, is a rare hematologic malignancy.
  • IVL is often diagnosed post-mortem due to its insidious presentation and tendency to infiltrate small blood vessels.

Observation:

  • This case details the early diagnosis of IVL in a patient presenting with neurological symptoms.
  • Electrodiagnostic testing revealed findings suggestive of polyneuropathy and myopathy.
  • A suspected paraneoplastic syndrome prompted further investigation.

Findings:

  • Muscle biopsy confirmed myopathy caused by direct neoplastic cell infiltration, establishing an early IVL diagnosis.
  • The patient received a standard chemotherapy regimen.

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  • Treatment led to improved neurological function and increased patient survival.

    • Implications:

    • Early diagnosis of IVL is achievable through a combination of clinical suspicion and diagnostic testing.
    • Prompt treatment can significantly improve outcomes for patients with IVL.
    • This case underscores the importance of considering IVL in patients with unexplained neurological deficits.