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Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
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[Acinetobacter, a nosocomial pathogen. Contribution of experimental models]
M L Joly-Guillou1, N Hidri, M Wolff
1Hôpital Louis-Mourier, service de microbiologie, 178, rue des Renouilliers, 92701 Colombes. marie-laure.joly-guillou@lmr.ap-hop-paris.fr
Epidemiology:
The increasing importance of Acinetobacter as a nosocomial pathogen responsible for outbreaks in intensive care units has been pointed out for twenty years. Today Acinetobacter infections are essentially pneumonia in patients under mechanical ventilation.
Experimental Models:
Most clinical isolates are resistant to b-lactam antibiotics as well as to other drugs. Animal models represent an essential step between in vivo testing an
Human Therapeutics:
The majority of strains are multi-resistant to antibiotics and the infections they cause are difficult to treat. Isolated or combined Sulbactam has often been used with success.
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