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Midazolam sedation for upper gastrointestinal endoscopy: comparison between the states of patients in partial and

Tatsuaki Ishiguro1, Chizuru Ishiguro, Goichi Ishiguro

  • 1Department of Surgical Oncology, University of Tokyo, Ishiguro Geka Hospital, Fukagawa City, Hokkaido, Japan.

Hepato-Gastroenterology
|May 9, 2002
PubMed
Abstract

Insights

Achieving complete amnesia during endoscopy with midazolam is feasible in most patients. Key factors influencing amnesia include midazolam dosage and prior hypnotic medication use.

Area of Science:

  • Anesthesiology
  • Gastroenterology

Background:

  • Midazolam is a common anesthetic for endoscopic procedures.
  • Complete amnesia is desirable for patient comfort during endoscopy.
  • Optimal midazolam dosing for complete amnesia requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy of midazolam for achieving complete amnesia during upper gastrointestinal endoscopy.
  • To identify factors influencing the achievement of complete amnesia.

Main Methods:

  • 133 patients undergoing endoscopy received intravenous midazolam.
  • Sedation efficacy was assessed by patient recall after flumazenil administration.
  • Physiological parameters (pulse, blood pressure, oxygen saturation) were monitored.

Main Results:

  • Complete amnesia was achieved in 75.9% of patients.
  • Minor physiological changes observed did not lead to serious complications.
  • Midazolam dose per body weight and habitual hypnotic use were significant factors for amnesia.

Conclusions:

  • Midazolam can effectively produce complete amnesia for upper gastrointestinal endoscopy without significant adverse effects.
  • Patient's midazolam dose and history of hypnotic use are crucial for achieving amnesia.

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