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Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and
B Kotoński1, J Wilczek, J Madej
1Department of Biochemistry, Agricultural University of Wroclaw, Poland.
Acta Biochimica Polonica
|May 9, 2002
Abstract:
An approximately threefold increase in glycogenolytic activity of the neutral alpha-1,4-glucosidase and a twofold increase in the same activity of the acid isoform have been found in extracts of anaplastic astrocytoma and glioblastoma multiforme tumors of brain tissue. "Maltase activity" of the respective enzymes increased by 60-80% in both kinds of tumor extracts. However a significant decrease in a-amylase and almost complete disappearance of phosphorylase activities have also been found in both kinds of tumors.