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Related Experiment Videos

Cerebral blood flow and cognitive dysfunction after coronary surgery.

Hanne Abildstrom1, Peter Høgh, Bjørn Sperling

  • 1Department of Anesthesia, Rigshospitalet, Copenhagen University Hospital, Denmark. habil@rh.dk

The Annals of Thoracic Surgery
|May 9, 2002
PubMed
Summary

Postoperative cognitive dysfunction after coronary surgery is not linked to changes in cerebral blood flow (CBF). This study found a uniform decrease in CBF after surgery, unrelated to cognitive outcomes.

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Area of Science:

  • Neurology
  • Cardiovascular Surgery
  • Medical Imaging

Background:

  • Postoperative cognitive dysfunction (POCD) after cardiac surgery is a concern.
  • Potential causes include embolic events and reduced cerebral perfusion.
  • This study examines the link between POCD and regional cerebral blood flow (CBF) after coronary surgery.

Purpose of the Study:

  • To investigate the association between cognitive dysfunction and changes in regional cerebral blood flow (CBF).
  • To assess global and regional CBF using single photon emission computed tomography (SPECT) in coronary surgery patients.

Main Methods:

  • SPECT and neuropsychological testing were performed on 15 coronary surgery patients before and after surgery.
  • Global and regional CBF were measured.

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  • Cognitive dysfunction was defined as a Z score above 2.

    • Main Results:

    • Preoperative global CBF was lower in patients than controls.
    • Global CBF significantly decreased after surgery in patients.
    • No significant differences in regional CBF were found, and no correlation existed between cognitive function and CBF.

    Conclusions:

    • A significant, uniform decrease in CBF occurs after coronary surgery.
    • This CBF decrease is not correlated with postoperative cognitive dysfunction.