Spontaneous esophageal perforation presenting as meningitis
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Updated: Oct 1, 2026

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Published on: July 14, 2020
Carlo C Jurani1, Gerald L Early, Shauna R Roberts
1Department of General Surgery, University of Kansas, Kansas City 66160-7119, USA.
Abstract:
This report describes a unique case of spontaneous esophageal perforation (Boerhaave's syndrome) presenting as meningitis. After a delay in diagnosis (16 days), the patient was successfully treated with debridement, primary closure, and drainage. Although rare, central nervous system infections have been reported in association with esophageal perforation caused by instrumentation, trauma, and malignancy. We report this case of spontaneous esophageal perforation giving rise to meningitis.
Insights
This case study highlights spontaneous esophageal perforation, a rare cause of meningitis. Prompt surgical intervention led to successful patient recovery despite diagnostic delays.
Area of Science:
- Gastroenterology
- Neurology
- Infectious Diseases
Background:
- Boerhaave's syndrome, or spontaneous esophageal perforation, is a rare but life-threatening condition.
- Central nervous system infections secondary to esophageal perforation are infrequently reported, often linked to instrumentation, trauma, or malignancy.
Observation:
- A patient presented with symptoms mimicking meningitis.
- A significant delay in diagnosis (16 days) occurred due to the unusual presentation.
Findings:
- The patient was diagnosed with spontaneous esophageal perforation presenting as meningitis.
- Successful treatment involved debridement, primary closure, and drainage of the affected area.
Implications:
- This case underscores the importance of considering esophageal perforation in the differential diagnosis of meningitis, even in the absence of typical risk factors.
- Early recognition and intervention are crucial for favorable outcomes in Boerhaave's syndrome with central nervous system involvement.
Related Concept Videos
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus.
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Bacterial Meningitis I: Introduction
Bacterial Meningitis
Viral Meningitis
Bacterial Meningitis II: Pathophysiology