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Blackwater fever treated with artemether.
V Khandelwal1, H Udawat, M R Kumhar
1Department of Medicine, JLN Medical College, Ajmer.
Summary
Blackwater fever, a severe malaria complication, involves red blood cell breakdown and hemoglobin in urine. This case highlights successful treatment of quinine-induced blackwater fever using artemether.
Area of Science:
- Infectious Diseases
- Hematology
- Pharmacology
Background:
- Blackwater fever is a rare, severe complication of falciparum malaria.
- It is characterized by acute intravascular hemolysis, fever, and hemoglobinuria.
- Quinine, an antimalarial drug, has been associated with triggering blackwater fever.
Observation:
- A case of blackwater fever occurred in a patient following quinine administration.
- The patient presented with classic symptoms of sudden intravascular hemolysis, fever, and hemoglobinuria.
- This adverse reaction highlights a potential risk associated with quinine treatment for malaria.
Findings:
- The presented case demonstrates a successful treatment outcome for blackwater fever.
- Artemether, an artemisinin derivative, was utilized as the therapeutic agent.
- The successful use of artemether suggests its efficacy in managing this severe malaria complication.
Implications:
- This case underscores the importance of monitoring for adverse drug reactions during malaria treatment.
- It provides evidence for artemether as a viable and effective treatment option for blackwater fever.
- Further research may explore the mechanisms of quinine-induced blackwater fever and optimal management strategies.