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The insulin-like growth factor system as a therapeutic target in colorectal cancer
1Department of Zoology, University of Oxford, UK. bass.hassan@zoo.ox.ac.uk
Abstract:
The purpose of this review is to examine recent evidence that investigates the role of the insulin-like growth factor (IGF) system in colorectal cancer. We concentrate on the evidence that makes the case for the investigation of strategies that might be used to disrupt the IGF system in prevention and treatment. Even though the weight of evidence suggests that components of the IGF system may be appropriate targets, there are a lack of studies that make a systematic characterisation of all the system components in human colorectal cancer. It is anticipated that this information, and the new therapeutic molecules which follow, will impact on the prevention and treatment of patients with this disease.
Insights
This review explores the insulin-like growth factor (IGF) system
Area of Science:
- Oncology
- Endocrinology
- Molecular Biology
Background:
- The insulin-like growth factor (IGF) system plays a crucial role in cellular processes.
- Aberrant IGF system activity is implicated in various cancers, including colorectal cancer (CRC).
Purpose of the Study:
- To review current evidence on the IGF system's role in colorectal cancer.
- To evaluate the potential of targeting the IGF system for CRC prevention and treatment.
Main Methods:
- Systematic literature review of recent studies.
- Analysis of evidence supporting IGF system components as therapeutic targets in CRC.
Main Results:
- Growing evidence suggests IGF system components are viable targets for CRC intervention.
- A significant gap exists in systematically characterizing all IGF system components in human CRC.
Conclusions:
- Targeting the IGF system holds promise for novel CRC prevention and treatment strategies.
- Further research is needed for comprehensive characterization of the IGF system in CRC to develop new therapies.