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Updated: Aug 14, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
[Cardiovascular events linked to the new diagnostic categories of diabetes mellitus]
I González Tejón1, M Pomares Sajkiewick, M Rovira España
1Area Básica de Salud Dr. Carles Ribas, Barcelona, Spain.
Objective:
To study the cardiovascular events linked to the new diagnostic categories of diabetes mellitus proposed by the American Diabetes Association.
Design:
Descriptive cross-sectional study.Setting. Urban health district.Participants. 2248 patients > 14, selected by simple random sampling from the medical records archive.
Main Measurements:
Through the medical records review, patients were classified into those with normal glucaemia, those intolerant to glucose when fasting (IGF) and those with type-2 diabetes mellitus (DM2). Patients were studied for cardiovascular events, ischaemic cardiopathy, cerebrovascular disease and peripheral arteriopathy. The likelihood of such events in patients with IGF and DM2 was compared with normal-glucose patients through logistical regression, adjustment for age, gender, hypertension, hypercholesterolaemia, hypertriglyceridaemia and tobacco dependency.
Results:
1677 patients were classified: 1237 with normal glucaemia, 175 with IGF and 265 with DM2. The DM2 patients were more likely to have at least one cardiovascular event (OR, 2.7; 95% CI, 1.7-4.4), ischaemic cardiopathy (OR, 2.0; 95% CI, 1.1-3.6), cerebrovascular disease (OR, 3.0; 95% CI, 1.4-6.6) or peripheral arteriopathy (OR, 2.9; 95% CI, 1.2-7.7). Results reached no statistical significance in patients with IGF, though these were more likely to suffer a cardiovascular event (OR, 1.1; 95% CI, 0.6-2.1), ischaemic cardiopathy (OR, 1.1; 95% CI, 0.3-4.4), cerebrovascular disease (OR, 1.5; 95% CI, 0.5-4.1) or peripheral arteriopathy (OR, 1.2; 95% CI, 0.3-4.6).
Conclusions:
Patients with DM2 are more likely to present cardiovascular events, a phenomenon not seen in the case of IGF.
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