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Updated: Jul 15, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Stem cell characteristics of human trabecular bone-derived cells
V Sottile1, C Halleux, F Bassilana
1Research, Novartis Pharma AG, CH-4002 Basel, Switzerland.
Abstract:
Human trabecular bone-derived cells (HTBs) have been used for many years as osteoblast progenitors. In this study we tested whether HTBs have stem cell characteristics; that is, whether they are pluripotent and able to self-renew. We show that HTBs readily differentiate into osteoblasts, chondrocytes, and adipocytes if subjected to the appropriate differentiating conditions. Importantly, differentiation into these three lineages is maintained in single cell clones derived by limiting dilution, following expansion over more than 20 cumulative population doublings. We conclude that cultures of HTBs are equivalent to cultures of "mesenchymal stem cells" (MSCs) isolated from bone marrow.
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