13C-NMR study of 4-azasteroids in solution and solid state
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Updated: Oct 1, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Jacek W Morzycki1, Iwona Wawer, Agnieszka Gryszkiewicz
1University of Bialystok, Institute of Chemistry, al. Pilsudskiego 11/4, Poland. morzycki@noc.uwb.edu.pl
Abstract:
A group of biologically active 4-azasteroids was studied by 13C-NMR spectroscopy in solution and in the solid phase. A full assignment of signals in the spectra of samples in chloroform was performed for thirteen 4-azasteroids using two-dimensional techniques. Substituent and steric effects of a nitrogen atom, and their influence on chemical shifts of the neighboring carbon atoms are discussed. CP MAS spectra were obtained for five 4-azasteroids including finasteride. The spectra confirmed polymorphism of the latter compound. In addition to the polymorphic forms that are already known, a new molecular complex of finasteride with dioxane is reported.
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